Searchable abstracts of presentations at key conferences in endocrinology

ea0032p757 | Obesity | ECE2013

Adiponectin and leptin actions on DNA synthesis and cell death of porcine myoblasts are dependent on the cellular milieu and related to ERK1/2 signalling

Kuzinski Judith , Will Katja , Kalbe Claudia , Maak Steffen , Palin Marie-France , Rehfeldt Charlotte

Cross-talk between adipose tissue and skeletal muscle could be mediated in part by adipokines secreted from adipose tissue. Previously, we observed that adiponectin but not leptin decreased DNA synthesis rate in proliferating porcine myoblasts in growth factor-supplemented serum-free medium (GF-SFM) after 48-h exposure (Will et al. 2012). To further elucidate the effects of adiponectin and leptin on muscle cell growth and their mode of action, this study was conducted...

ea0022p261 | Developmental endocrinology | ECE2010

An inadequate maternal dietary protein level during pregnancy in pigs alters the expression of corticosteroid receptors and 11β-hydroxysteroid dehydrogenase isoforms in the placenta and fetal brain

Kanitz Ellen , Grabner Maria , Tuchscherer Margret , Brussow Klaus-Peter , Stabenow Bernd , Rehfeldt Charlotte , Metges Cornelia C , Otten Winfried

Imbalanced maternal nutrition during pregnancy can cause fetal growth retardation, metabolic changes and alterations of the hypothalamic–pituitary–adrenal (HPA) system in the offspring. Here, we investigated the effects of maternal low and high protein diets during pregnancy in pigs on materno-fetal HPA regulation and expression of glucocorticoid receptor (GR), mineralocorticoid receptor (MR), 11β-hydroxysteroid dehydrogenase 1 and 2 (11β-HSD1 and 11β-...